The Science Department would like to invite you all to our first Science Seminar of the semester funded through our SOHLIS program on Wednesday, September 25th at 7 PM via zoom. Our seminar speaker Dr. Victor Garcia joins us from the Department of Pharmacology at New York Medical College (NYMC) where he currently serves as an Assistant Professor. Dr. Garcia holds the pivotal role of Director of the Associated Medical Schools of New York (AMSNY) and NYMC School of Medicine (SOM) linkage program. This initiative aims to broaden the representation of students from ethnically/racially underrepresented backgrounds in medicine and those facing educational or economic disadvantages. Dr. Garcia’s multifaceted contributions to academia and medicine underscore his dedication to advancing both scientific knowledge and equitable access to medical education and healthcare. Below you will find the information on our seminar including the link to register for this zoom event:
Title of talk: GPR75: A Key Regulator in Obesity and its Impact on End Organ Health
This presentation will focus on the role of 20-Hydroxyeicosatetraenoic acid (20-HETE), a vasoactive and proinflammatory lipid, and its high-affinity receptor, GPR75, across metabolic disorders including obesity, diabetes, and liver disease. Notably, in collaboration with Regeneron, several human loss-of-function GPR75 variants were identified. These variants are associated with leanness and protection against obesity. The presentation will also discuss the development of novel 20-HETE receptor blockers and agonists, including their role in the prevention and reversal of obesity-related cardiometabolic complications including liver diseases such as NAFLD/MAFLD. The research highlights how the 20-HETE/GPR75 pairing not only regulates inflammation, blood pressure, and vascular remodeling, it contributes to obesity and obesity-drive end organ damage.
Zoom registration link: https://shorturl.at/wlyzo
